Drug Interaction Still Causing Problems
I went to the Gastroenterologist Wednesday afternoon, and he did X-rays of my abdomen to determine if I was as constipated as he thought I would be, based on my symptoms. He was surprised to find that nothing in my colon was hard or compacted. After examining me, he has come to the conclusion that my problem is caused by spasms of the digestive tract, rather than weak muscles, as he had been telling me it was. So, now he thinks my trouble is exactly the opposite of what he had thought previously!! He prescribed Triavil, which relaxes the colon muscles, and he said I should feel much better by Monday.
I've learned my lesson though, so I specifically asked him if he was sure I could take this med with my Parkinson's meds. He said he did not think this would be a problem, but to ask my pharmacist. Full of hope that he had found a way to stop my very uncomfortable situation, I called our drugstore on the way home to be sure he had it in stock. But, when hubby came back from the drugstore, he didn't bring in the prescription bag. He said the pharmacist said his computer all but crashed when he put in the medicine, it produced such a strong warning that this was a dangerous combination with my other PD meds!!
At first I handled the news stoically, but later on that evening I went through a rough time of being very depressed, with lots of crying. I called my doctor's nurse first thing Thursday morning to let her know I couldn't take it, and to remind her that he would see Selegiline listed in the interaction information, rather than Zelepar, which is just a dissolving form of Selegiline. I think that must be why he didn't realize I couldn't take it.
Anyhow, I haven't heard back from him yet, so DH and I decided it was time to take matters in our own hands. We went enzyme, herb, and spice shopping, as I have been doing some research on my own about Irritable Bowel Syndrome (IBS), and I found some things that should help, without causing problems.
Yesterday, I started taking Turmeric, St. John's Wort, and Acidophilus capsules. DH's Oncologist has had him on Turmeric ever since he had colon cancer, and his doctor had already suggested I use it. We had our usual Date Day today, and I continued to belch a lot all day, but did not have any nausea at all, or my usual sensation as if my food was sitting at the top of my throat all day. I'm encouraged that I will find a way to calm my system down and get things back to closer to normal, whether my Gastro can find a medicine I can take or not.
I'm still very wobbly, though, so I used the cane just about everywhere we went today, and I'm using it in the house tonight, too. It may be that it's just going to take awhile to recover from the really bad state I was in Sunday, plus I may still have some of the Cortisol in my system. I'll have to see if I can find something about how long it stays in the system after getting an injection. Or, it may be that the St. John's Wort, added to my other PD meds, is giving me an overdose of Levadopa.
That's what makes figuring this all out so difficult, as too much PD meds makes for jerky movements, called Dyskinesia. If you've seen Michael J. Fox jerking around, you've seen it. When PWP have been on meds for a long time their systems process the Levadopa in a very unpredictable way, and you see these wild jerking movements. But early on, if the meds aren't strong enough, you see tremors. It's hard for me to tell if my wobbliness is tremor or jerking, so I can't tell, based on that, if I'm getting too little or too much Levadopa. My hands are only shaking ever so slightly, which makes me think I'm not getting too much. My Neuro will know when he sees me.
By then I should have heard from my Gastro doctor, and I'll know if the herbs are going to do any good or cause any problems. I will be doing more research, too, to be sure there are no contraindications of these OTC with my prescriptions.
I've learned my lesson though, so I specifically asked him if he was sure I could take this med with my Parkinson's meds. He said he did not think this would be a problem, but to ask my pharmacist. Full of hope that he had found a way to stop my very uncomfortable situation, I called our drugstore on the way home to be sure he had it in stock. But, when hubby came back from the drugstore, he didn't bring in the prescription bag. He said the pharmacist said his computer all but crashed when he put in the medicine, it produced such a strong warning that this was a dangerous combination with my other PD meds!!
At first I handled the news stoically, but later on that evening I went through a rough time of being very depressed, with lots of crying. I called my doctor's nurse first thing Thursday morning to let her know I couldn't take it, and to remind her that he would see Selegiline listed in the interaction information, rather than Zelepar, which is just a dissolving form of Selegiline. I think that must be why he didn't realize I couldn't take it.
Anyhow, I haven't heard back from him yet, so DH and I decided it was time to take matters in our own hands. We went enzyme, herb, and spice shopping, as I have been doing some research on my own about Irritable Bowel Syndrome (IBS), and I found some things that should help, without causing problems.
Yesterday, I started taking Turmeric, St. John's Wort, and Acidophilus capsules. DH's Oncologist has had him on Turmeric ever since he had colon cancer, and his doctor had already suggested I use it. We had our usual Date Day today, and I continued to belch a lot all day, but did not have any nausea at all, or my usual sensation as if my food was sitting at the top of my throat all day. I'm encouraged that I will find a way to calm my system down and get things back to closer to normal, whether my Gastro can find a medicine I can take or not.
I'm still very wobbly, though, so I used the cane just about everywhere we went today, and I'm using it in the house tonight, too. It may be that it's just going to take awhile to recover from the really bad state I was in Sunday, plus I may still have some of the Cortisol in my system. I'll have to see if I can find something about how long it stays in the system after getting an injection. Or, it may be that the St. John's Wort, added to my other PD meds, is giving me an overdose of Levadopa.
That's what makes figuring this all out so difficult, as too much PD meds makes for jerky movements, called Dyskinesia. If you've seen Michael J. Fox jerking around, you've seen it. When PWP have been on meds for a long time their systems process the Levadopa in a very unpredictable way, and you see these wild jerking movements. But early on, if the meds aren't strong enough, you see tremors. It's hard for me to tell if my wobbliness is tremor or jerking, so I can't tell, based on that, if I'm getting too little or too much Levadopa. My hands are only shaking ever so slightly, which makes me think I'm not getting too much. My Neuro will know when he sees me.
By then I should have heard from my Gastro doctor, and I'll know if the herbs are going to do any good or cause any problems. I will be doing more research, too, to be sure there are no contraindications of these OTC with my prescriptions.
Labels: "Parkinson's", cane, difficulty walking, drug interaction, exhaustion, gas, Gastroenterologist, IBS, Levadopa, nausea, pharmacist, prescriptions, Selegiline, steroids, tremors, Triavil, X-rays, Zelepar



10 Comments:
At 10/07/2007 5:33 AM ,
Jackie said...
You might find some help at www.helpforibs.com/ I get Heather's newletters and find tons of great info in them.
I must admit since becoming Vegan my IBS isn't the hell it was for all the years since I was a child due to a tropical disease I got then leaving a lot of scar tissue in my colon.
I find it worrying that you are on so many meds and who knows how they all react to each other.
At 10/07/2007 6:22 AM ,
Dirty Butter said...
Thanks for the link, Jackie. I can see I have a lot of unlearning to do about what to eat. I'm not sure if he gave me an "official" diagnosis of IBS or not, but he did say it was colon spasms.
And you're right, I do take an awful lot of medicine. But I have lots of things wrong with me LOL!!
I did stop the St. John's Wort, as I read some more and decided I'd better wait until the Neurologist told me that one was OK for me.
At 10/07/2007 4:04 PM ,
Marion said...
I decided much the same, about taking some pro-active measures on my own, DB. After Graham saw a Naturopathic doctor, he got much better, with the diet she placed him on.
I am going to do the same...I already use different herbal remedies for various things. I find I do very well on herbal medications, as opposed to the chemical compositions.
And what I meet makes a great difference as to how I feel...certain foods do not agree!
At 10/07/2007 4:18 PM ,
Dirty Butter said...
I'll have to be just as careful with my choice of natural compounds as I would anything else, Marion. Really, they ARE medicines. You just don't have to have a prescription to get them.
I'm planning on asking my Neuro about Macuna Pruriens, too. This is a natural source of Levadopa, which is not supposed to be as hard on the digestive system. But I wouldn't dare take that unless he concurred.
At 10/07/2007 4:42 PM ,
Marsha said...
Another suggestion: try eliminating wheat from your diet for a couple of weeks and see if that helps. My little had a difficult time digesting wheat when she was younger, which led me on a journey of discovering that many, many people have this problem with wheat and do not realize it. I hope you find a solution and your belly feels better soon. That doctor makes me so mad, he should have checked his computer before letting you leave with a prescription for something you couldn't have.
At 10/07/2007 7:05 PM ,
Dirty Butter said...
Oh, Marsha, I hope you're wrong about wheat. I know there are people with celiac disease who can't eat anything with wheat in it, but I can't imagine what eating would be like without it!
I'll admit I'm disappointed that my Gastro didn't catch this, but I have been too impressed with him for years to get mad. Besides, earlier this year my Neuro also didn't catch an interaction that my pharmacist did catch.
At 10/08/2007 5:44 AM ,
Joe said...
I have two bits of info that you may find helpful: First, it is simple enough to find out if it really is celiac sprue disease by having blood work done - specifically by testing immunoglobulin levels.With celiac, they test 4, sometimes 5, different Ig levels, and it is important that you do not change your diet prior to the testing. Intolerance to Gluten is what causes the Ig levels to be off. If you change your diet befor testing you will get a false negative result.
Second: I am not sure if this applies to you or not, but I sat bolt upright in bed this morning remembering a patient I once took care of that had every symptom you described...we finally realized it was one of his medications that was causing the problem - Prilosec. We took him off that and voila, problem solved. Since then we have had other patients with the same issues, and changed them to a different med to treat their acid reflux and found it helped several(not all)of them - just a thought. I wish you well, and I will continue to wrack my brain for anything else that may be of use.
At 10/08/2007 6:05 AM ,
Dirty Butter said...
This is really strange, Joe. I have been on Protonix for years, but my insurance changed, and it was going to cost me $100 a month if I did not go to the generic form. My Gastro really didn't recommend the change, but said he understood, and prescribed it.
I just realized this week, while double checking every med I take for interactions, that I'm on Omeprazole, which is the generic form of PRILOSEC, not Protonix!! Obviously, I'll be talking to my doctor about that, for sure!!
Thanks so much! Sorry I made you bolt straight up in bed, though. LOL
At 10/13/2007 4:26 AM ,
Jackie said...
What you need is a medical doctor who has changed over to alternative medicine. There are many these days and have the advantage of knowing what you need med wise and what herb/homeopathic would replace some meds without harm.
Wish you could go for a week to Dr McDougall's health center. He is brilliant and I love his sensible newsletters (and recipes). http://www.drmcdougall.com/
At 10/13/2007 11:38 AM ,
Dirty Butter said...
I'm doing all the research on alternative medicines I can from the Internet, Jackie. I drink several different herbal teas, plus now I've added the enteric coated peppermint oil gel caps to my growing list of meds. The coating is supposed to keep them from dissolving in the stomach. I'm not really sure if I will be able to use the peppermint, though. I have really bad GERD, and I'm feeling the menthol effect all the way up to my throat, even though I take the gel cap with the minimum amount of water. I'm also taking turmeric capsules to calm my colon and as an excellent antioxidant.
I'll be sure to check out your Dr. McDougall's site.
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